Extracellular Vesicles From 3xTg-AD Mouse and Alzheimer’s Disease Patient Astrocytes Impair Neuroglial and Vascular Components

Extracellular Vesicles From 3xTg-AD Mouse and Alzheimer’s Disease Patient Astrocytes Impair Neuroglial and Vascular Components

Astrocytes are specialized glial cells that are essential components of the neurovascular unit (NVU) and are involved in neurodevelopment, brain maintenance and repair, and neurodegeneration. Astrocytes mediate these processes by releasing cellular mediators such as extracellular vesicles (EVs). EVs...

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Bibliographic Details
Main Authors: Luis Alfonso González-Molina, Juan Villar-Vesga, Julián Henao-Restrepo, Andrés Villegas, Francisco Lopera, Gloria Patricia Cardona-Gómez, Rafael Posada-Duque
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
3xTg-AD mice
astrocytes
human astrocytes
extracellular vesicles
endothelial disruption
familiar Alzheimer’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.593927/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.593927/full

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