CRISPR deletion of a SINE-VNTR-Alu (SVA_67) retrotransposon demonstrates its ability to differentially modulate gene expression at the MAPT locus

CRISPR deletion of a SINE-VNTR-Alu (SVA_67) retrotransposon demonstrates its ability to differentially modulate gene expression at the MAPT locus

BackgroundSINE-VNTR-Alu (SVA) retrotransposons are hominid-specific elements which have been shown to play important roles in processes such as chromatin structure remodelling and regulation of gene expression demonstrating that these repetitive elements exert regulatory functions. We have previousl...

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Bibliographic Details
Main Authors: Alexander Fröhlich, Lauren S. Hughes, Ben Middlehurst, Abigail L. Pfaff, Vivien J. Bubb, Sulev Koks, John P. Quinn
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Neurology
Subjects:
SINE-VNTR-Alu
retrotransposon
CRISPR
gene regulation
gene expression
Parkinson’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2023.1273036/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2023.1273036/full

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