Target organ expression and biomarker characterization of chemokine CCL21 in systemic sclerosis associated pulmonary arterial hypertension

Target organ expression and biomarker characterization of chemokine CCL21 in systemic sclerosis associated pulmonary arterial hypertension

IntroductionSystemic sclerosis (SSc) is a heterogenous disorder that appears to result from interplay between vascular pathologies, tissue fibrosis and immune processes, with evidence for deregulation of chemokines, which normally control immune trafficking. We recently identified altered levels of...

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Main Authors: Henriette Didriksen, Øyvind Molberg, Adi Mehta, Suzana Jordan, Vyacheslav Palchevskiy, Håvard Fretheim, Einar Gude, Thor Ueland, Cathrine Brunborg, Torhild Garen, Øyvind Midtvedt, Arne K. Andreassen, Fridtjof Lund-Johansen, Oliver Distler, John Belperio, Anna-Maria Hoffmann-Vold
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
systemic sclerosis
CCL21
pulmonary arteria hypertension
ELISA Enzyme-linked immunosorbent assay
Luminex (xMAP) method
Anti-CCL21
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.991743/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.991743/full

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