Functional connectivity of the cortico-subcortical sensorimotor loop is modulated by the severity of nigrostriatal dopaminergic denervation in Parkinson’s Disease

Functional connectivity of the cortico-subcortical sensorimotor loop is modulated by the severity of nigrostriatal dopaminergic denervation in Parkinson’s Disease

Abstract To assess if the severity of nigrostriatal innervation loss affects the functional connectivity (FC) of the sensorimotor cortico-striato-thalamic-cortical loop (CSTCL) in Parkinson’s Disease (PD), Resting-State functional MRI and 18F-DOPA PET data, simultaneously acquired on a hybrid PET/MR...

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Bibliographic Details
Main Authors: Mario Quarantelli, Andrea Quattrone, Alessia Sarica, Francesco Cicone, Giuseppe Lucio Cascini, Aldo Quattrone
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-022-00385-w

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https://doi.org/10.1038/s41531-022-00385-w

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