Boosting antitumor response with PSMA-targeted immunomodulatory VLPs, harboring costimulatory TNFSF ligands and GM-CSF cytokine

Boosting antitumor response with PSMA-targeted immunomodulatory VLPs, harboring costimulatory TNFSF ligands and GM-CSF cytokine

Therapeutic strategies based on immunomodulation have improved cancer therapy. Most approaches target co-stimulatory pathways or the inhibition of immunosuppressive mechanisms, to enhance immune response and overcome the immune tolerance of tumors. Here, we propose a novel platform to deliver target...

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Bibliographic Details
Main Authors: Soledad Palameta, Andrea J. Manrique-Rincón, Jessica M. Toscaro, Isadora F. Semionatto, Matheus C. Fonseca, Rhubia S.M. Rosa, Luciana P. Ruas, Paulo S.L. Oliveira, Marcio C. Bajgelman
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Molecular Therapy: Oncolytics
Subjects:
VLP
4-1BB
OX40
GM-CSF
PSMA
immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770522000274

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http://www.sciencedirect.com/science/article/pii/S2372770522000274

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