Synthesis of Substituted 1,2-Dihydroisoquinolines by Palladium-Catalyzed Cascade Cyclization–Coupling of Trisubstituted Allenamides with Arylboronic Acids

Synthesis of Substituted 1,2-Dihydroisoquinolines by Palladium-Catalyzed Cascade Cyclization–Coupling of Trisubstituted Allenamides with Arylboronic Acids

1,2-Dihydroisoquinolines are important compounds due to their biological and medicinal activities, and numerous approaches to their synthesis have been reported. Recently, we reported a facile synthesis of trisubstituted allenamides via <i>N</i>-acetylation followed by DBU-promoted isome...

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Bibliographic Details
Main Authors: Masahiro Yoshida, Ryunosuke Imaji, Shinya Shiomi
Format: Article
Language:English
Published: MDPI AG 2024-06-01
Series:Molecules
Subjects:
allenamide
cascade reaction
palladium catalyst
cyclization
coupling
organoboronic compound
Online Access:https://www.mdpi.com/1420-3049/29/12/2917

Internet

https://www.mdpi.com/1420-3049/29/12/2917

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