Multi-omics analysis in human retina uncovers ultraconserved cis-regulatory elements at rare eye disease loci

Multi-omics analysis in human retina uncovers ultraconserved cis-regulatory elements at rare eye disease loci

Abstract Cross-species genome comparisons have revealed a substantial number of ultraconserved non-coding elements (UCNEs). Several of these elements have proved to be essential tissue- and cell type-specific cis-regulators of developmental gene expression. Here, we characterize a set of UCNEs as ca...

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Bibliographic Details
Main Authors: Victor Lopez Soriano, Alfredo Dueñas Rey, Rajarshi Mukherjee, Genomics England Research Consortium, Frauke Coppieters, Miriam Bauwens, Andy Willaert, Elfride De Baere
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45381-1

Internet

https://doi.org/10.1038/s41467-024-45381-1

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