Effect of co-administration of morphine and nicotine on cardiovascular function in two-kidney one clip hypertensive (2K1C) rats
Cardiovascular morbidity and mortality are potentiated with smoking and hypertension. The aim of this study was to investigate the effects of morphine and nicotine co-administration on cardiovascular function in two-kidney one-clip hypertensive (2K1C) rats. Thirty-two male rats were divided into fo...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2013-08-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/2345 |
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| author | Motahareh Zeinivand Mohammad Reza Rahman Mohammad Allatavakoli Ali Shamsizadeh Gholamhossin Hassanshahi Hossien Rezazadeh Ali Asghar Pourshanazari |
| author_facet | Motahareh Zeinivand Mohammad Reza Rahman Mohammad Allatavakoli Ali Shamsizadeh Gholamhossin Hassanshahi Hossien Rezazadeh Ali Asghar Pourshanazari |
| author_sort | Motahareh Zeinivand |
| collection | DOAJ |
| description |
Cardiovascular morbidity and mortality are potentiated with smoking and hypertension. The aim of this study was to investigate the effects of morphine and nicotine co-administration on cardiovascular function in two-kidney one-clip hypertensive (2K1C) rats. Thirty-two male rats were divided into four groups as follow: Vehicle, morphine, nicotine and nicotine + morphine. All drugs were administered for 8 weeks. Baroreflex sensitivity (BRS), heart rate and blood pressure were measured using a Power Lab data acquisition. Plasma rennin activity (PRA) and serum concentration of nitric oxide (NO) were measured using Elisa method. To induce hypertension, the renal artery of left kidney was clipped for 8 weeks. A significant decrease in systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) was observed in nicotine + morphine group compared to vehicle and nicotine groups (p<0.05). Serum concentration of NO was lower in nicotine + morphine group compared to morphine group and significantly higher than nicotine group. The BRS was lower in the nicotine + morphine group compared to other groups. The PRA level was higher in nicotine + morphine compared to morphine group but it was higher than nicotine group. This study demonstrated that prolonged co-consumption of morphine and nicotinedecreased PRA and blood pressure and increased the serum concentration of NO in hypertensive rats. Co-administration of morphine and nicotine decreased BRS in 2kic hypertensive rats probably via central nervous system.
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| first_indexed | 2024-04-24T23:32:15Z |
| format | Article |
| id | doaj.art-38cc02c409ae46969822c2fb8e4dad17 |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:32:15Z |
| publishDate | 2013-08-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-38cc02c409ae46969822c2fb8e4dad172024-03-15T14:32:50ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2013-08-0113310.17305/bjbms.2013.2345221Effect of co-administration of morphine and nicotine on cardiovascular function in two-kidney one clip hypertensive (2K1C) ratsMotahareh Zeinivand0Mohammad Reza Rahman1Mohammad Allatavakoli2Ali Shamsizadeh3Gholamhossin Hassanshahi4Hossien Rezazadeh5Ali Asghar Pourshanazari6Physiology-Pharmacology Research Center, Enq St. Rafsanjan University of Medical SciencesPhysiology-Pharmacology Research Center, Enq St. Rafsanjan University of Medical SciencesPhysiology-Pharmacology Research Center, Enq St. Rafsanjan University of Medical SciencesPhysiology-Pharmacology Research Center, Enq St. Rafsanjan University of Medical SciencesMolecular Medicine Research Centre, Enq St. RafsanjanUniversity of Medical SciencesPhysiology-Pharmacology Research Center, Enq St. Rafsanjan University of Medical SciencesPhysiology-Pharmacology Research Center, Enq St. Rafsanjan University of Medical Sciences Department of Physiology, Hezar-Jerib St. Isfahan University of Medical Sciences Cardiovascular morbidity and mortality are potentiated with smoking and hypertension. The aim of this study was to investigate the effects of morphine and nicotine co-administration on cardiovascular function in two-kidney one-clip hypertensive (2K1C) rats. Thirty-two male rats were divided into four groups as follow: Vehicle, morphine, nicotine and nicotine + morphine. All drugs were administered for 8 weeks. Baroreflex sensitivity (BRS), heart rate and blood pressure were measured using a Power Lab data acquisition. Plasma rennin activity (PRA) and serum concentration of nitric oxide (NO) were measured using Elisa method. To induce hypertension, the renal artery of left kidney was clipped for 8 weeks. A significant decrease in systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) was observed in nicotine + morphine group compared to vehicle and nicotine groups (p<0.05). Serum concentration of NO was lower in nicotine + morphine group compared to morphine group and significantly higher than nicotine group. The BRS was lower in the nicotine + morphine group compared to other groups. The PRA level was higher in nicotine + morphine compared to morphine group but it was higher than nicotine group. This study demonstrated that prolonged co-consumption of morphine and nicotinedecreased PRA and blood pressure and increased the serum concentration of NO in hypertensive rats. Co-administration of morphine and nicotine decreased BRS in 2kic hypertensive rats probably via central nervous system. https://www.bjbms.org/ojs/index.php/bjbms/article/view/2345baroreflex sensitivityblood pressurenitric oxidemorphinenicotine |
| spellingShingle | Motahareh Zeinivand Mohammad Reza Rahman Mohammad Allatavakoli Ali Shamsizadeh Gholamhossin Hassanshahi Hossien Rezazadeh Ali Asghar Pourshanazari Effect of co-administration of morphine and nicotine on cardiovascular function in two-kidney one clip hypertensive (2K1C) rats Biomolecules & Biomedicine baroreflex sensitivity blood pressure nitric oxide morphine nicotine |
| title | Effect of co-administration of morphine and nicotine on cardiovascular function in two-kidney one clip hypertensive (2K1C) rats |
| title_full | Effect of co-administration of morphine and nicotine on cardiovascular function in two-kidney one clip hypertensive (2K1C) rats |
| title_fullStr | Effect of co-administration of morphine and nicotine on cardiovascular function in two-kidney one clip hypertensive (2K1C) rats |
| title_full_unstemmed | Effect of co-administration of morphine and nicotine on cardiovascular function in two-kidney one clip hypertensive (2K1C) rats |
| title_short | Effect of co-administration of morphine and nicotine on cardiovascular function in two-kidney one clip hypertensive (2K1C) rats |
| title_sort | effect of co administration of morphine and nicotine on cardiovascular function in two kidney one clip hypertensive 2k1c rats |
| topic | baroreflex sensitivity blood pressure nitric oxide morphine nicotine |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/2345 |
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