Modulating autophagic flux via ROS-responsive targeted micelles to restore neuronal proteostasis in Alzheimer's disease

Modulating autophagic flux via ROS-responsive targeted micelles to restore neuronal proteostasis in Alzheimer's disease

Compromised autophagy and defective lysosomal clearance significantly contribute to impaired neuronal proteostasis, which represents a hallmark of Alzheimer's disease (AD) and other age-related neurodegenerative disorders. Growing evidence has implicated that modulating autophagic flux, instead...

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Bibliographic Details
Main Authors: Shuting Xu, Peng Yang, Kang Qian, Yixian Li, Qian Guo, Pengzhen Wang, Ran Meng, Jing Wu, Jinxu Cao, Yunlong Cheng, Minjun Xu, Qizhi Zhang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-05-01
Series:Bioactive Materials
Subjects:
Autophagic flux
ROS-Responsive micelle system
Brain-neuron targeting
Rapamycin
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X21004321

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http://www.sciencedirect.com/science/article/pii/S2452199X21004321

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