Detection of genes mutations in cerebrospinal fluid circulating tumor DNA from neoplastic meningitis patients using next generation sequencing

Detection of genes mutations in cerebrospinal fluid circulating tumor DNA from neoplastic meningitis patients using next generation sequencing

Abstract Background This study profiled the somatic genes mutations and the copy number variations (CNVs) in cerebrospinal fluid (CSF)-circulating tumor DNA (ctDNA) from patients with neoplastic meningitis (NM). Methods A total of 62 CSF ctDNA samples were collected from 58 NM patients for the next...

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Bibliographic Details
Main Authors: Yue Zhao, Jun Ying He, Jun Zhao Cui, Zi-Qi Meng, Yue Li Zou, Xiao Su Guo, Xin Chen, Xueliang Wang, Li-Tian Yan, Wei Xin Han, Chunyan Li, Li Guo, Hui Bu
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Cancer
Subjects:
Neoplastic meningitis
Cerebrospinal fluid ctDNA
Next generation sequencing
Cancer-associated genes mutations
PI3K-Akt pathway
Online Access:http://link.springer.com/article/10.1186/s12885-020-07172-x

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http://link.springer.com/article/10.1186/s12885-020-07172-x

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