Plasma Signaling Factors in Patients With Langerhans Cell Histiocytosis (LCH) Correlate With Relative Frequencies of LCH Cells and T Cells Within Lesions

Plasma Signaling Factors in Patients With Langerhans Cell Histiocytosis (LCH) Correlate With Relative Frequencies of LCH Cells and T Cells Within Lesions

Langerhans cell histiocytosis (LCH) lesions contain an inflammatory infiltrate of immune cells including myeloid-derived LCH cells. Cell-signaling proteins within the lesion environment suggest that LCH cells and T cells contribute majorly to the inflammation. Foxp3+ regulatory T cells (Tregs) are e...

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Bibliographic Details
Main Authors: Jenée Mitchell, Egle Kvedaraite, Tatiana von Bahr Greenwood, Magda Lourda, Jan-Inge Henter, Stuart P. Berzins, George Kannourakis
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pediatrics
Subjects:
Langerhans cell histiocytosis (LCH)
LCH cells
FoxP3+ regulatory T cells (Treg)
mucosal associated invariant T cells (MAIT)
active TGF-β
cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2022.872859/full

Internet

https://www.frontiersin.org/articles/10.3389/fped.2022.872859/full

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