K63-linked ubiquitination of DYRK1A by TRAF2 alleviates Sprouty 2-mediated degradation of EGFR

K63-linked ubiquitination of DYRK1A by TRAF2 alleviates Sprouty 2-mediated degradation of EGFR

Abstract Dual specificity tyrosine phosphorylation regulated kinase 1A, DYRK1A, functions in multiple cellular pathways, including signaling, endocytosis, synaptic transmission, and transcription. Alterations in dosage of DYRK1A leads to defects in neurogenesis, cell growth, and differentiation, and...

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Bibliographic Details
Main Authors: Pengshan Zhang, Zhe Zhang, Yinkun Fu, Ying Zhang, Michael P. Washburn, Laurence Florens, Min Wu, Chen Huang, Zhaoyuan Hou, Man Mohan
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03887-2

Internet

https://doi.org/10.1038/s41419-021-03887-2

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