Immunomodulation Induced During Interferon-α Therapy Impairs the Anti-HBV Immune Response Through CD24+CD38hi B Cells

Immunomodulation Induced During Interferon-α Therapy Impairs the Anti-HBV Immune Response Through CD24+CD38hi B Cells

Type I interferon is widely used for antiviral therapy, yet has yielded disappointing results toward chronic HBV infection. Here we identify that PEG-IFNα-2b therapy toward persistent infection in humans is a double-edged sword of both immunostimulation and immunomodulation. Our studies of this rand...

Full description

Bibliographic Details
Main Authors: Binqing Fu, Dongyao Wang, Xiaokun Shen, Chuang Guo, Yanyan Liu, Ying Ye, Rui Sun, Jiabin Li, Zhigang Tian, Haiming Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
anti-virus function
immunomodulatory effects
CD24+CD38hi B
chronic hepatitis B virus infection
Peg-IFNα-2b
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.591269/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.591269/full

Similar Items