Oxaloacetate treatment preserves motor function in SOD1G93A mice and normalizes select neuroinflammation-related parameters in the spinal cord

Oxaloacetate treatment preserves motor function in SOD1G93A mice and normalizes select neuroinflammation-related parameters in the spinal cord

Abstract Amyotrophic lateral sclerosis (ALS) remains a devastating motor neuron disease with limited treatment options. Oxaloacetate treatment has a neuroprotective effect in rodent models of seizure and neurodegeneration. Therefore, we treated the ALS model superoxide dismutase 1 (SOD1) G93A mice w...

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Bibliographic Details
Main Authors: Sudheer K. Tungtur, Heather M. Wilkins, Robert S. Rogers, Yomna Badawi, Jessica M. Sage, Abdulbaki Agbas, Omar Jawdat, Richard J. Barohn, Russell H. Swerdlow, Hiroshi Nishimune
Format: Article
Language:English
Published: Nature Portfolio 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-90438-6

Internet

https://doi.org/10.1038/s41598-021-90438-6

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