Amide proton transfer MRI differentiates between progressive multifocal leukoencephalopathy and malignant brain tumors: a pilot study
Abstract Background Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nerve system caused by the John Cunningham virus. On MRI, PML may sometimes appear similar to primary central nervous system lymphoma (PCNSL) and glioblastoma multiforme (GBM). The purpose...
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | BMC Medical Imaging |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12880-022-00959-3 |
| _version_ | 1797973412938776576 |
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| author | Hirofumi Koike Minoru Morikawa Hideki Ishimaru Reiko Ideguchi Masataka Uetani Takeshi Hiu Takayuki Matsuo Mitsuharu Miyoshi |
| author_facet | Hirofumi Koike Minoru Morikawa Hideki Ishimaru Reiko Ideguchi Masataka Uetani Takeshi Hiu Takayuki Matsuo Mitsuharu Miyoshi |
| author_sort | Hirofumi Koike |
| collection | DOAJ |
| description | Abstract Background Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nerve system caused by the John Cunningham virus. On MRI, PML may sometimes appear similar to primary central nervous system lymphoma (PCNSL) and glioblastoma multiforme (GBM). The purpose of this pilot study was to evaluate the potential of amide proton transfer (APT) imaging for differentiating PML from PCNSL and GBM. Methods Patients with PML (n = 4; two men; mean age 52.3 ± 6.1 years), PCNSL (n = 7; four women; mean age 74.4 ± 5.8 years), or GBM (n = 11; 6 men; mean age 65.0 ± 15.2 years) who underwent APT-CEST MRI between January 2021 and September 2022 were retrospectively evaluated. Magnetization transfer ratio asymmetry (MTRasym) values were measured on APT imaging using a region of interest within the lesion. Receiver operating characteristics curve analysis was used to determine diagnostic cutoffs for MTRasym. Results The mean MTRasym values were 0.005 ± 0.005 in the PML group, 0.025 ± 0.005 in the PCNSL group, and 0.025 ± 0.009 in the GBM group. There were significant differences in MTRasym between PML and PCNSL (P = 0.023), and between PML and GBM (P = 0.015). For differentiating PML from PCNSL, an MTRasym threshold of 0.0165 gave diagnostic sensitivity, specificity, positive predictive value, and negative predictive value of 100% (all). For differentiating PML from GBM, an MTRasym threshold of 0.015 gave diagnostic sensitivity, specificity, positive predictive value, and negative predictive value of 100%, 90.9%, 80.0%, and 100%, respectively. Conclusion MTRasym values obtained from APT imaging allowed patients with PML to be clearly discriminated from patients with PCNSL or GBM. |
| first_indexed | 2024-04-11T04:03:52Z |
| format | Article |
| id | doaj.art-38e11f03751a47838cbc4fdcbb233770 |
| institution | Directory Open Access Journal |
| issn | 1471-2342 |
| language | English |
| last_indexed | 2024-04-11T04:03:52Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Imaging |
| spelling | doaj.art-38e11f03751a47838cbc4fdcbb2337702023-01-01T12:30:23ZengBMCBMC Medical Imaging1471-23422022-12-0122111010.1186/s12880-022-00959-3Amide proton transfer MRI differentiates between progressive multifocal leukoencephalopathy and malignant brain tumors: a pilot studyHirofumi Koike0Minoru Morikawa1Hideki Ishimaru2Reiko Ideguchi3Masataka Uetani4Takeshi Hiu5Takayuki Matsuo6Mitsuharu Miyoshi7Department of Radiology, Nagasaki University Graduate School of Biomedical SciencesDepartment of Radiology, Nagasaki University HospitalDepartment of Radiology, Nagasaki University HospitalDepartment of Radioisotope Medicine, Nagasaki University Graduate School of Biomedical SciencesDepartment of Radiology, Nagasaki University Graduate School of Biomedical SciencesDepartment of Neurosurgery, Nagasaki University Graduate School of Biomedical SciencesDepartment of Neurosurgery, Nagasaki University Graduate School of Biomedical SciencesMR Application and Workflow, GE Healthcare JapanAbstract Background Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nerve system caused by the John Cunningham virus. On MRI, PML may sometimes appear similar to primary central nervous system lymphoma (PCNSL) and glioblastoma multiforme (GBM). The purpose of this pilot study was to evaluate the potential of amide proton transfer (APT) imaging for differentiating PML from PCNSL and GBM. Methods Patients with PML (n = 4; two men; mean age 52.3 ± 6.1 years), PCNSL (n = 7; four women; mean age 74.4 ± 5.8 years), or GBM (n = 11; 6 men; mean age 65.0 ± 15.2 years) who underwent APT-CEST MRI between January 2021 and September 2022 were retrospectively evaluated. Magnetization transfer ratio asymmetry (MTRasym) values were measured on APT imaging using a region of interest within the lesion. Receiver operating characteristics curve analysis was used to determine diagnostic cutoffs for MTRasym. Results The mean MTRasym values were 0.005 ± 0.005 in the PML group, 0.025 ± 0.005 in the PCNSL group, and 0.025 ± 0.009 in the GBM group. There were significant differences in MTRasym between PML and PCNSL (P = 0.023), and between PML and GBM (P = 0.015). For differentiating PML from PCNSL, an MTRasym threshold of 0.0165 gave diagnostic sensitivity, specificity, positive predictive value, and negative predictive value of 100% (all). For differentiating PML from GBM, an MTRasym threshold of 0.015 gave diagnostic sensitivity, specificity, positive predictive value, and negative predictive value of 100%, 90.9%, 80.0%, and 100%, respectively. Conclusion MTRasym values obtained from APT imaging allowed patients with PML to be clearly discriminated from patients with PCNSL or GBM.https://doi.org/10.1186/s12880-022-00959-3Magnetic resonance imagingAmide proton transfer imagingProgressive multifocal leukoencephalopathyPrimary central nervous system lymphomaGlioblastoma multiforme |
| spellingShingle | Hirofumi Koike Minoru Morikawa Hideki Ishimaru Reiko Ideguchi Masataka Uetani Takeshi Hiu Takayuki Matsuo Mitsuharu Miyoshi Amide proton transfer MRI differentiates between progressive multifocal leukoencephalopathy and malignant brain tumors: a pilot study BMC Medical Imaging Magnetic resonance imaging Amide proton transfer imaging Progressive multifocal leukoencephalopathy Primary central nervous system lymphoma Glioblastoma multiforme |
| title | Amide proton transfer MRI differentiates between progressive multifocal leukoencephalopathy and malignant brain tumors: a pilot study |
| title_full | Amide proton transfer MRI differentiates between progressive multifocal leukoencephalopathy and malignant brain tumors: a pilot study |
| title_fullStr | Amide proton transfer MRI differentiates between progressive multifocal leukoencephalopathy and malignant brain tumors: a pilot study |
| title_full_unstemmed | Amide proton transfer MRI differentiates between progressive multifocal leukoencephalopathy and malignant brain tumors: a pilot study |
| title_short | Amide proton transfer MRI differentiates between progressive multifocal leukoencephalopathy and malignant brain tumors: a pilot study |
| title_sort | amide proton transfer mri differentiates between progressive multifocal leukoencephalopathy and malignant brain tumors a pilot study |
| topic | Magnetic resonance imaging Amide proton transfer imaging Progressive multifocal leukoencephalopathy Primary central nervous system lymphoma Glioblastoma multiforme |
| url | https://doi.org/10.1186/s12880-022-00959-3 |
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