CD200 in dentate gyrus improves depressive-like behaviors of mice through enhancing hippocampal neurogenesis via alleviation of microglia hyperactivation

CD200 in dentate gyrus improves depressive-like behaviors of mice through enhancing hippocampal neurogenesis via alleviation of microglia hyperactivation

Abstract Background Neuroinflammation and microglia play critical roles in the development of depression. Cluster of differentiation 200 (CD200) is an anti-inflammatory glycoprotein that is mainly expressed in neurons, and its receptor CD200R1 is primarily in microglia. Although the CD200–CD200R1 pa...

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Bibliographic Details
Main Authors: Xi Chen, Qian-Qian Cui, Xiao-Hai Hu, Jian Ye, Zi-Cun Liu, Yuan-Xi Mei, Fang Wang, Zhuang-Li Hu, Jian-Guo Chen
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Neuroinflammation
Subjects:
Depression
CD200
Chronic social defeat stress
Microglia
Neurogenesis
Online Access:https://doi.org/10.1186/s12974-023-02836-4

Internet

https://doi.org/10.1186/s12974-023-02836-4

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