OCT4-induced oligodendrocyte progenitor cells promote remyelination and ameliorate disease

OCT4-induced oligodendrocyte progenitor cells promote remyelination and ameliorate disease

Abstract The generation of human oligodendrocyte progenitor cells (OPCs) may be therapeutically valuable for human demyelinating diseases such as multiple sclerosis. Here, we report the direct reprogramming of human somatic cells into expandable induced OPCs (iOPCs) using a combination of OCT4 and a...

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Bibliographic Details
Main Authors: Wonjin Yun, Kyung-Ah Choi, Insik Hwang, Jie Zheng, Minji Park, Wonjun Hong, Ah-Young Jang, Jeong Hee Kim, Wonji Choi, Dae-Sung Kim, In Yong Kim, Yong Jun Kim, Ying Liu, Byung Sun Yoon, Gyuman Park, Gwonhwa Song, Sunghoi Hong, Seungkwon You
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-021-00199-z

Internet

https://doi.org/10.1038/s41536-021-00199-z

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