Insulin-induced gene 2 protects against hepatic ischemia–reperfusion injury via metabolic remodeling

Insulin-induced gene 2 protects against hepatic ischemia–reperfusion injury via metabolic remodeling

Abstract Background Hepatic ischemia–reperfusion (IR) injury is the primary reason for complications following hepatectomy and liver transplantation (LT). Insulin-induced gene 2 (Insig2) is one of several proteins that anchor the reticulum in the cytoplasm and is essential for metabolism and inflamm...

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Bibliographic Details
Main Authors: Yichao Wu, Changbiao Li, Abid Ali Khan, Kangchen Chen, Renyi Su, Shengjun Xu, Yiyang Sun, Fengqiang Gao, Kai Wang, Xiaodong Wang, Zhengxing Lian, Shuo Wang, Mengyuan Yu, Xin Hu, Fan Yang, Shusen Zheng, Nasha Qiu, Zhikun Liu, Xiao Xu
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Translational Medicine
Subjects:
Insulin-induced gene 2
Hepatic ischemia–reperfusion injury
Pentose phosphate pathway
Glycolysis
Online Access:https://doi.org/10.1186/s12967-023-04564-y

Internet

https://doi.org/10.1186/s12967-023-04564-y

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