Deficiency of peroxisomal NUDT7 stimulates de novo lipogenesis in hepatocytes

Deficiency of peroxisomal NUDT7 stimulates de novo lipogenesis in hepatocytes

Summary: Here, we found that heterozygous null of peroxisomal Nudt7 (Nudt7+/−) induced the typical NAFLD features, i.e. increased levels of hepatic triglyceride (TG) and fatty acid (FA), infiltration of inflammatory cells, impaired glucose tolerance and insulin sensitivity, and stimulation of lipoly...

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Bibliographic Details
Main Authors: Jinsoo Song, In-Jeoung Baek, Sujeong Park, Jinjoo Oh, Deokha Kim, Kyung Song, Mi Kyung Kim, Hye Won Lee, Byoung Kuk Jang, Eun-Jung Jin
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:iScience
Subjects:
Biological sciences
Human metabolism
Cell biology
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222014079

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http://www.sciencedirect.com/science/article/pii/S2589004222014079

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