The Transcription Factor EB (TFEB) Sensitizes the Heart to Chronic Pressure Overload

The Transcription Factor EB (TFEB) Sensitizes the Heart to Chronic Pressure Overload

The transcription factor EB (TFEB) promotes protein degradation by the autophagy and lysosomal pathway (ALP) and overexpression of TFEB was suggested for the treatment of ALP-related diseases that often affect the heart. However, TFEB-mediated ALP induction may perturb cardiac stress response. We us...

Full description

Bibliographic Details
Main Authors: Sebastian Wundersitz, Cristina Pablo Tortola, Sibylle Schmidt, Ramon Oliveira Vidal, Melanie Kny, Alexander Hahn, Lukas Zanders, Hugo A. Katus, Sascha Sauer, Christian Butter, Friedrich C. Luft, Oliver J. Müller, Jens Fielitz
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
heart failure
left ventricular hypertrophy
transcription factor EB
Online Access:https://www.mdpi.com/1422-0067/23/11/5943

Internet

https://www.mdpi.com/1422-0067/23/11/5943

Similar Items