Differential expression of inhibitory receptor NKG2A distinguishes disease‐specific exhausted CD8+ T cells

Differential expression of inhibitory receptor NKG2A distinguishes disease‐specific exhausted CD8+ T cells

Abstract Exhausted CD8+ T (Tex) cells are caused by persistent antigenic stimulation during chronic viral infection or tumorigenesis. Tex cells upregulate and sustain the expressions of multiple immune inhibitory receptors (IRs). Blocking IRs of Tex cells, exemplified by PD‐1, can partially restore...

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Bibliographic Details
Main Authors: Xiangyu Chen, Yao Lin, Shuai Yue, Yang Yang, Xinxin Wang, Zhiwei Pan, Xiaofan Yang, Leiqiong Gao, Jing Zhou, Zhirong Li, Li Hu, Jianfang Tang, Qing Wu, Yifei Wang, Qin Tian, Yaxing Hao, Lifan Xu, Bo Zhu, Qizhao Huang, Lilin Ye
Format: Article
Language:English
Published: Wiley 2022-03-01
Series:MedComm
Subjects:
cancer immunotherapy
chronic viral infection
NKG2A
T cell exhaustion
Online Access:https://doi.org/10.1002/mco2.111

Internet

https://doi.org/10.1002/mco2.111

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