Study of the Activity and Possible Mechanism of Action of a Reversible Inhibitor of Recombinant Human KAT-2: A Promising Lead in Neurodegenerative and Cognitive Disorders

Abnormal levels of kynurenic acid (KYNA) in the human brain are believed to be connected to several central nervous system (CNS) diseases, therefore compounds which affect the production of this crucial metabolite are of interest in CNS drug development. The majority of KYNA production is accounted...

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Bibliographic Details
Main Authors: Alireza Nematollahi, Guanchen Sun, Gayan S. Jayawickrama, Jane R. Hanrahan, W. Bret Church
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/21/7/856