Wnt6 plays a complex role in maintaining human limbal stem/progenitor cells

Abstract The corneal epithelium is consistently regenerated by limbal stem/progenitor cells (LSCs), a very small population of adult stem cells residing in the limbus. Several Wnt ligands, including Wnt6, are preferentially expressed in the limbus. To investigate the role of Wnt6 in regulating proli...

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Bibliographic Details
Main Authors: Clémence Bonnet, Denise Oh, Hua Mei, Sarah Robertson, Derek Chang, Jean-Louis Bourges, Francine Behar-Cohen, Jie J. Zheng, Sophie X. Deng
Format: Article
Language:English
Published: Nature Portfolio 2021-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-00273-y