A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas

A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas

Gain-of-function Notch mutations are recurrent in mature small B cell lymphomas such as mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL), but the Notch target genes that contribute to B cell oncogenesis are largely unknown. We performed integrative analysis of Notch-regulated transc...

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Bibliographic Details
Main Authors: Russell J.H. Ryan, Jelena Petrovic, Dylan M. Rausch, Yeqiao Zhou, Caleb A. Lareau, Michael J. Kluk, Amanda L. Christie, Winston Y. Lee, Daniel R. Tarjan, Bingqian Guo, Laura K.H. Donohue, Shawn M. Gillespie, Valentina Nardi, Ephraim P. Hochberg, Stephen C. Blacklow, David M. Weinstock, Robert B. Faryabi, Bradley E. Bernstein, Jon C. Aster, Warren S. Pear
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Cell Reports
Subjects:
mantle cell lymphoma
chronic lymphocytic leukemia
lymphoma
Notch signaling
MYC
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717313712

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http://www.sciencedirect.com/science/article/pii/S2211124717313712

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