A Comprehensive Overview of the Cyclodipeptide Synthase Family Enriched with the Characterization of 32 New Enzymes

A Comprehensive Overview of the Cyclodipeptide Synthase Family Enriched with the Characterization of 32 New Enzymes

Cyclodipeptide synthases (CDPSs) use as substrates two amino acids activated as aminoacyl-tRNAs to synthesize cyclodipeptides in secondary metabolites biosynthetic pathways. Since the first description of a CDPS in 2002, the number of putative CDPSs in databases has increased exponentially, reaching...

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Bibliographic Details
Main Authors: Muriel Gondry, Isabelle B. Jacques, Robert Thai, Morgan Babin, Nicolas Canu, Jérôme Seguin, Pascal Belin, Jean-Luc Pernodet, Mireille Moutiez
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Microbiology
Subjects:
secondary metabolites
biosynthetic pathways
cyclodipeptide synthase
tRNA-dependent enzymes
diketopiperazine
activity prediction
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00046/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2018.00046/full

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