STAT3 gain-of-function is not responsible for low total IgE levels in patients with autoimmune chronic spontaneous urticaria

STAT3 gain-of-function is not responsible for low total IgE levels in patients with autoimmune chronic spontaneous urticaria

BackgroundThe pathogenesis of chronic spontaneous urticaria (CSU) has not been clarified entirely. Type IIb autoimmune chronic spontaneous urticaria (CSUaiTIIb) is a distinct subtype of CSU that is often difficult to treat and is connected to low levels of total IgE. Previous findings indicate that...

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Bibliographic Details
Main Authors: Merle Sauer, Jörg Scheffel, Stefan Frischbutter, Niklas Mahnke, Marcus Maurer, Thomas Burmeister, Karoline Krause, Martin Metz
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
autoimmune disease
autoreactivity
basophil activation test
chronic spontaneous urticaria
gain-of-function mutation
immunoglobulin E
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.902652/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.902652/full

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