Variations in candidalysin amino acid sequence influence toxicity and host responses

Variations in candidalysin amino acid sequence influence toxicity and host responses

ABSTRACT Candida albicans causes millions of mucosal infections in humans annually. Hyphal overgrowth on mucosal surfaces is frequently associated with tissue damage caused by candidalysin, a secreted peptide toxin that destabilizes the plasma membrane of host cells thereby promoting disease and imm...

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Bibliographic Details
Main Authors: Don N. Wickramasinghe, Claire M. Lyon, Sejeong Lee, Olivia W. Hepworth, Emily L. Priest, Corinne Maufrais, Adam P. Ryan, Emmanuelle Permal, Derek Sullivan, Brenda A. McManus, Bernhard Hube, Geraldine Butler, Christophe d'Enfert, Julian R. Naglik, Jonathan P. Richardson
Format: Article
Language:English
Published: American Society for Microbiology 2024-08-01
Series:mBio
Subjects:
Candida
candidalysin
fungus
toxin
epithelial
Online Access:https://journals.asm.org/doi/10.1128/mbio.03351-23

Internet

https://journals.asm.org/doi/10.1128/mbio.03351-23

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