Diastereoselective Formal 1,3-Dipolar Cycloaddition of Trifluoroethyl Amine-Derived Ketimines Enables the Desymmetrization of Cyclopentenediones

Diastereoselective Formal 1,3-Dipolar Cycloaddition of Trifluoroethyl Amine-Derived Ketimines Enables the Desymmetrization of Cyclopentenediones

In this research, a metal-free diastereoselective formal 1,3-dipolar cycloaddition of <i>N</i>-2,2,2-trifluoroethylisatin ketimines and cyclopentene-1,3-diones which can efficiently lead to the desymmetrization of cyclopentene-1,3-diones is developed. With the developed protocol, a serie...

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Bibliographic Details
Main Authors: Lin-Qiang Li, Jian-Qiang Zhao, Yan-Ping Zhang, Yong You, Zhen-Hua Wang, Zhen-Zhen Ge, Ming-Qiang Zhou, Wei-Cheng Yuan
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Molecules
Subjects:
desymmetrization
1,3-dipolar cycloaddition
cyclopentene-1,3-diones
trifluoroethyl amine-derived ketimines
polycyclic heterocycles
Online Access:https://www.mdpi.com/1420-3049/28/14/5372

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https://www.mdpi.com/1420-3049/28/14/5372

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