Effects of Epigenetic Modification of PGC-1α by a Chemical Chaperon on Mitochondria Biogenesis and Visual Function in Retinitis Pigmentosa

Effects of Epigenetic Modification of PGC-1α by a Chemical Chaperon on Mitochondria Biogenesis and Visual Function in Retinitis Pigmentosa

Retinitis pigmentosa (RP) is a hereditary blinding disease characterized by gradual photoreceptor death, which lacks a definitive treatment. Here, we demonstrated the effect of 4-phenylbutyric acid (PBA), a chemical chaperon that can suppress endoplasmic reticulum (ER) stress, in P23H mutant rhodops...

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Bibliographic Details
Main Authors: Yoko Ozawa, Eriko Toda, Kohei Homma, Hideto Osada, Norihiro Nagai, Kazuo Tsubota, Hideyuki Okano
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cells
Subjects:
retinitis pigmentosa
rhodopsin
ER stress
PGC-1α
mitochondria
Online Access:https://www.mdpi.com/2073-4409/11/9/1497

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https://www.mdpi.com/2073-4409/11/9/1497

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