The novel TRPA1 antagonist BI01305834 inhibits ovalbumin-induced bronchoconstriction in guinea pigs

The novel TRPA1 antagonist BI01305834 inhibits ovalbumin-induced bronchoconstriction in guinea pigs

Abstract Background Asthma is a chronic respiratory disease in which the nervous system plays a central role. Sensory nerve activation, amongst others via Transient Receptor Potential Ankyrin 1 (TRPA1) channels, contributes to asthma characteristics including cough, bronchoconstriction, mucus secret...

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Bibliographic Details
Main Authors: Mariska P. M. van den Berg, Susan Nijboer-Brinksma, I. Sophie T. Bos, Maarten van den Berge, David Lamb, Martijn van Faassen, Ido P. Kema, Reinoud Gosens, Loes E. M. Kistemaker
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Respiratory Research
Subjects:
Asthma
Airway hyperresponsiveness
Airway smooth muscle
Mast cell
Sensory neuron
Online Access:https://doi.org/10.1186/s12931-021-01638-7

Internet

https://doi.org/10.1186/s12931-021-01638-7

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