Comparative analysis of dose-dependent neurotoxic response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 N mice derived from three different sources

Comparative analysis of dose-dependent neurotoxic response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 N mice derived from three different sources

Abstract MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is commonly used to induce nigrostriatal defects to induce parkinsonism and/or parkinsonian syndrome, to replicate the lesions seen in Parkinson’s disease (PD), with use in numerous PD models in mice. It has been suggested that various biol...

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Bibliographic Details
Main Authors: Dong-Joo Hwang, Ki-Chun Kwon, Hyun-Keun Song, Kil-Soo Kim, Young-Suk Jung, Dae-Youn Hwang, Joon-Yong Cho
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Laboratory Animal Research
Subjects:
Parkinson’s disease
MPTP
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C57BL/6Nkorl
Mouse stock
Online Access:http://link.springer.com/article/10.1186/s42826-019-0012-2

Internet

http://link.springer.com/article/10.1186/s42826-019-0012-2

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