Individualized dynamic methylation-based analysis of cell-free DNA in postoperative monitoring of lung cancer

Individualized dynamic methylation-based analysis of cell-free DNA in postoperative monitoring of lung cancer

Abstract Background The feasibility of DNA methylation-based assays in detecting minimal residual disease (MRD) and postoperative monitoring remains unestablished. We aim to investigate the dynamic characteristics of cancer-related methylation signals and the feasibility of methylation-based MRD det...

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Bibliographic Details
Main Authors: Kezhong Chen, Guannan Kang, Zhihong Zhang, Analyn Lizaso, Stephan Beck, Iben Lyskjær, Olga Chervova, Bingsi Li, Haifeng Shen, Chenyang Wang, Bing Li, Heng Zhao, Xi Li, Fan Yang, Nnennaya Kanu, Jun Wang
Format: Article
Language:English
Published: BMC 2023-07-01
Series:BMC Medicine
Subjects:
Lung cancer
Postoperative surveillance
Circulating tumor DNA (ctDNA)
DNA methylation
Minimal residual disease (MRD)
Online Access:https://doi.org/10.1186/s12916-023-02954-z

Internet

https://doi.org/10.1186/s12916-023-02954-z

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