Consecutive Four-Component Coupling-Addition Aza-Anellation <i>Pictet</i>–<i>Spengler</i> Synthesis of Tetrahydro-<i>β</i>-Carbolines: An Optimized <i>Michael</i> Addition and Computational Study on the Aza-Anellation Step

Consecutive Four-Component Coupling-Addition Aza-Anellation <i>Pictet</i>–<i>Spengler</i> Synthesis of Tetrahydro-<i>β</i>-Carbolines: An Optimized <i>Michael</i> Addition and Computational Study on the Aza-Anellation Step

Starting from acid chlorides, alkynes, tryptamines, and acryloyl chloride, 21 densely substituted tetrahydro-<i>β</i>-carbolines were prepared in a four-component, one-pot reaction. In this study, the aza-<i>Michael</i> addition step to generate intermediate enaminones was op...

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Bibliographic Details
Main Authors: Kai Ries, Françoise A. Aouane, Thomas J. J. Müller
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Organics
Subjects:
aza-<i>Michael</i> addition
tetrahydro-<i>β</i>-carbolines
catalysis
one-pot reaction
multicomponent reaction
ytterbium (III) triflate
Online Access:https://www.mdpi.com/2673-401X/4/3/25

Internet

https://www.mdpi.com/2673-401X/4/3/25

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