Novel Tools for Comprehensive Functional Analysis of LDLR (Low-Density Lipoprotein Receptor) Variants

Novel Tools for Comprehensive Functional Analysis of LDLR (Low-Density Lipoprotein Receptor) Variants

Familial hypercholesterolemia (FH) is an autosomal-dominant disorder caused mainly by substitutions in the low-density lipoprotein receptor (<i>LDLR</i>) gene, leading to an increased risk of premature cardiovascular diseases. Tremendous advances in sequencing techniques have resulted in...

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Bibliographic Details
Main Authors: Jacek Jasiecki, Monika Targońska, Anna Janaszak-Jasiecka, Magdalena Chmara, Monika Żuk, Leszek Kalinowski, Krzysztof Waleron, Bartosz Wasąg
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
LDL receptor
LDLR
low-density lipoprotein
LDL uptake
familial hypercholesterolemia
CRISPR
Online Access:https://www.mdpi.com/1422-0067/24/14/11435

Internet

https://www.mdpi.com/1422-0067/24/14/11435

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