The role of the interferon/JAK-STAT axis in driving islet HLA-I hyperexpression in type 1 diabetes

The role of the interferon/JAK-STAT axis in driving islet HLA-I hyperexpression in type 1 diabetes

The hyperexpression of human leukocyte antigen class I (HLA-I) molecules on pancreatic beta-cells is widely accepted as a hallmark feature of type 1 diabetes pathogenesis. This response is important clinically since it may increase the visibility of beta-cells to autoreactive CD8+ T-cells, thereby a...

Full description

Bibliographic Details
Main Authors: Mark A. Russell, Sarah J. Richardson, Noel G. Morgan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Endocrinology
Subjects:
HLA-I
STAT1
STAT2
pancreatic islet
type 1 diabetes
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1270325/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1270325/full

Similar Items