T cell therapy targeting a public neoantigen in microsatellite instable colon cancer reduces in vivo tumor growth

T cell therapy targeting a public neoantigen in microsatellite instable colon cancer reduces in vivo tumor growth

T-cell receptor (TCR) transfer is an attractive strategy to increase the number of cancer-specific T cells in adoptive cell therapy. However, recent clinical and pre-clinical findings indicate that careful consideration of the target antigen is required to limit the risk of off-target toxicity. Dire...

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Bibliographic Details
Main Authors: Else M. Inderberg, Sébastien Wälchli, Marit R. Myhre, Sissel Trachsel, Hilde Almåsbak, Gunnar Kvalheim, Gustav Gaudernack
Format: Article
Language:English
Published: Taylor & Francis Group 2017-04-01
Series:OncoImmunology
Subjects:
adoptive t-cell therapy (act)
colon cancer
immunotherapy
neoantigen
t cell receptor (tcr)
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1302631

Internet

http://dx.doi.org/10.1080/2162402X.2017.1302631

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