A non-lethal malarial infection results in reduced drug metabolizing enzyme expression and drug clearance in mice

A non-lethal malarial infection results in reduced drug metabolizing enzyme expression and drug clearance in mice

Abstract Background Given the central importance of anti-malarial drugs in the treatment of malaria, there is a need to understand the effect of Plasmodium infection on the broad spectrum of drug metabolizing enzymes. Previous studies have shown reduced clearance of quinine, a treatment for Plasmodi...

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Bibliographic Details
Main Authors: Sylvie M. Mimche, Choon-myung Lee, Ken H. Liu, Patrice N. Mimche, R. Donald Harvey, Thomas J. Murphy, Beatrice A. Nyagode, Dean P. Jones, Tracey J. Lamb, Edward T. Morgan
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Malaria Journal
Subjects:
Plasmodium chabaudi chabaudi
Drug metabolism
Cytochrome P450
Liver
Gene expression
Online Access:http://link.springer.com/article/10.1186/s12936-019-2860-5

Internet

http://link.springer.com/article/10.1186/s12936-019-2860-5

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