Palmitoyltransferase ZDHHC3 Aggravates Nonalcoholic Steatohepatitis by Targeting S‐Palmitoylated IRHOM2

Palmitoyltransferase ZDHHC3 Aggravates Nonalcoholic Steatohepatitis by Targeting S‐Palmitoylated IRHOM2

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Abstract Underestimation of the complexity of pathogenesis in nonalcoholic steatohepatitis (NASH) significantly encumbers development of new drugs and targeted therapy strategies. Inactive rhomboid protein 2 (IRHOM2) has a multifunctional role in regulating inflammation, cell survival, and immunorea...

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Bibliographic Details
Main Authors: Minxuan Xu, Jun Tan, Liancai Zhu, Chenxu Ge, Yi Zhang, Fufeng Gao, Xianling Dai, Qin Kuang, Jie Chai, Benkui Zou, Bochu Wang
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:Advanced Science
Subjects:
hepatosteatosis
inactive rhomboid protein 2 (IRHOM2)
nonalcoholic steatohepatitis (NASH)
Palmitoylation
zinc finger DHHC‐type palmitoyltransferase 3 (ZDHHC3)
tripartite motif containing 31 (TRIM31)
Online Access:https://doi.org/10.1002/advs.202302130

Internet

https://doi.org/10.1002/advs.202302130

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