Anticancer Properties of 3-Dietoxyphosphorylfuroquinoline-4,9-dione

Anticancer Properties of 3-Dietoxyphosphorylfuroquinoline-4,9-dione

Herein, the antitumor activity of a novel synthetic analog with 5,8-quinolinedione scaffold, diethyl (2-(2-chlorophenyl)-4,9-dioxo-4,9-dihydrofuro [3,2-<i>g</i>]quinolin-3-yl)phosphonate (<b>AJ-418</b>) was investigated on two breast cancer cell lines. This analog was selecte...

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Bibliographic Details
Main Authors: Joanna Drogosz-Stachowicz, Katarzyna Gach-Janczak, Marek Mirowski, Jacek Pietrzak, Tomasz Janecki, Anna Janecka
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Molecules
Subjects:
quinolinediones
cytotoxic activity
apoptosis
DNA damage
maximum tolerated dose
Online Access:https://www.mdpi.com/1420-3049/28/7/3128

Internet

https://www.mdpi.com/1420-3049/28/7/3128

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