Cross-Species Comparison of the Pan-RAF Inhibitor LY3009120’s Anti-Tumor Effects in Equine, Canine, and Human Malignant Melanoma Cell Lines

Cross-Species Comparison of the Pan-RAF Inhibitor LY3009120’s Anti-Tumor Effects in Equine, Canine, and Human Malignant Melanoma Cell Lines

Malignant melanomas (MMs) are the abnormal proliferation of melanocytes and are one of the lethal skin cancers in humans, equines, and canines. Accordingly, MMs in companion animals can serve as naturally occurring animal models, completing conventional cancer models. The common constitutive activat...

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Bibliographic Details
Main Authors: Yu Gao, Eva-Maria Packeiser, Sophia Wendt, Anett Sekora, Jessika-Maximiliane V. Cavalleri, Barbara Pratscher, Moosheer Alammar, Maja Hühns, Bertram Brenig, Christian Junghanss, Ingo Nolte, Hugo Murua Escobar
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Genes
Subjects:
equine malignant melanoma
canine malignant melanoma
Pan-RAF inhibitor
LY3009120
DNA sequencing
genetic evaluation
Online Access:https://www.mdpi.com/2073-4425/15/2/202

Internet

https://www.mdpi.com/2073-4425/15/2/202

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