Osteopontin inhibits osteoarthritis progression via the OPN/CD44/PI3K signal axis

Osteopontin inhibits osteoarthritis progression via the OPN/CD44/PI3K signal axis

Chondrocyte degeneration and extracellular matrix component loss are the primary causes of osteoarthritis (OA). OA can be treated by inhibiting chondrocyte degeneration and increasing extracellular matrix component secretion. Osteopontin (OPN), a multifunctional protein, has gained immense attention...

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Bibliographic Details
Main Authors: Qing Liu, Hao Zeng, Yuhao Yuan, Zhiwei Wang, Ziyi Wu, Wei Luo
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-01-01
Series:Genes and Diseases
Subjects:
Cartilage degeneration
Cartilage matrix
CD44
Osteoarthritis
Osteopontin
Phosphatidylinositol-3-kinase
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304220300787

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http://www.sciencedirect.com/science/article/pii/S2352304220300787

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