Quantifying the mapping precision of genome-wide association studies using whole-genome sequencing data

Quantifying the mapping precision of genome-wide association studies using whole-genome sequencing data

Abstract Background Understanding the mapping precision of genome-wide association studies (GWAS), that is the physical distances between the top associated single-nucleotide polymorphisms (SNPs) and the causal variants, is essential to design fine-mapping experiments for complex traits and diseases...

Full description

Bibliographic Details
Main Authors: Yang Wu, Zhili Zheng, Peter M. Visscher, Jian Yang
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Genome Biology
Subjects:
Genome-wide association studies
Mapping precision
False positive rate
Whole genome sequencing
Imputation
Online Access:http://link.springer.com/article/10.1186/s13059-017-1216-0

Similar Items

Similar Items