Disruption of FDPS/Rac1 axis radiosensitizes pancreatic ductal adenocarcinoma by attenuating DNA damage response and immunosuppressive signalling

Disruption of FDPS/Rac1 axis radiosensitizes pancreatic ductal adenocarcinoma by attenuating DNA damage response and immunosuppressive signalling

Summary: Background: Radiation therapy (RT) has a suboptimal effect in patients with pancreatic ductal adenocarcinoma (PDAC) due to intrinsic and acquired radioresistance (RR). Comprehensive bioinformatics and microarray analysis revealed that cholesterol biosynthesis (CBS) is involved in the RR of...

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Main Authors: Parthasarathy Seshacharyulu, Sushanta Halder, Ramakrishna Nimmakayala, Satyanarayana Rachagani, Sanjib Chaudhary, Pranita Atri, Ramakanth Chirravuri-Venkata, Michel M. Ouellette, Joseph Carmicheal, Shailendra K. Gautam, Raghupathy Vengoji, Shuo Wang, Sicong Li, Lynette Smith, Geoffrey A. Talmon, Kelsey Klute, Quan Ly, Bradley N Reames, Jean L Grem, Lyudmyla Berim, James C Padussis, Sukhwinder Kaur, Sushil Kumar, Moorthy P. Ponnusamy, Maneesh Jain, Chi Lin, Surinder K Batra
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:EBioMedicine
Subjects:
FDPS
PDAC
Radioresistance
Zoledronic acid
Radiotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421005661

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http://www.sciencedirect.com/science/article/pii/S2352396421005661

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