Improved overall survival in patients with high-grade serous ovarian cancer is associated with CD16a+ immunologic neighborhoods containing NK cells, T cells and macrophages

Improved overall survival in patients with high-grade serous ovarian cancer is associated with CD16a+ immunologic neighborhoods containing NK cells, T cells and macrophages

BackgroundFor patients with high grade serous carcinoma of the ovary (HGSC), survival rates have remained static for the last half century. Despite the presence of tumor mutations and infiltration of immune cells, existing immunotherapies have achieved little success against HGSC. These observations...

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Bibliographic Details
Main Authors: Sarah Nersesian, Riley J. Arseneau, Jorge P. Mejia, Stacey N. Lee, Lauren P. Westhaver, Nigel W. Griffiths, Stephanie R. Grantham, Liliane Meunier, Laudine Communal, Avik Mukherjee, Anne-Marie Mes-Masson, Thomas Arnason, Brad H. Nelson, Jeanette E. Boudreau
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
natural killer (NK) cell
ovarian cancer
high grade serous cancer
spatial biology
CD16A
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1307873/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1307873/full

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