Transgenic Mice Overexpressing Human Alpha-1 Antitrypsin Exhibit Low Blood Pressure and Altered Epithelial Transport Mechanisms in the Inactive and Active Cycles

Transgenic Mice Overexpressing Human Alpha-1 Antitrypsin Exhibit Low Blood Pressure and Altered Epithelial Transport Mechanisms in the Inactive and Active Cycles

Human alpha-1 antitrypsin (hAAT) is a versatile protease inhibitor, but little is known about its targets in the aldosterone-sensitive distal nephron and its role in electrolyte balance and blood pressure control. We analyzed urinary electrolytes, osmolality, and blood pressure from hAAT transgenic...

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Bibliographic Details
Main Authors: Lauren P. Liu, Mohammed F. Gholam, Ahmed Samir Elshikha, Tamim Kawakibi, Nasseem Elmoujahid, Hassan H. Moussa, Sihong Song, Abdel A. Alli
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Physiology
Subjects:
hAAT
blood pressure
electrolytes
kidney
epithelial Na+ channel
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.710313/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.710313/full

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