Non-HLA angiotensin-type-1 receptor autoantibodies mediate the long-term loss of grafted neurons in Parkinson’s disease models

Non-HLA angiotensin-type-1 receptor autoantibodies mediate the long-term loss of grafted neurons in Parkinson’s disease models

Abstract Background Clinical trials have provided evidence that transplants of dopaminergic precursors, which may be replaced by new in vitro stem cell sources, can integrate into the host tissue, and alleviate motor symptoms in Parkinson´s disease (PD). In some patients, deterioration of graft func...

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Bibliographic Details
Main Authors: Ana I. Rodríguez-Pérez, Pablo Garrido-Gil, Maria García-Garrote, Ana Muñoz, Juan A. Parga, Jose Luis Labandeira-García, Jannette Rodríguez-Pallares
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Stem Cell Research & Therapy
Subjects:
Angiotensin
AT1
Autoimmunity
Cell grafts
Cell transplantation
Microglia
Online Access:https://doi.org/10.1186/s13287-024-03751-y

Internet

https://doi.org/10.1186/s13287-024-03751-y

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