Hypoxia-Mediated ATF4 Induction Promotes Survival in Detached Conditions in Metastatic Murine Mammary Cancer Cells

Hypoxia-Mediated ATF4 Induction Promotes Survival in Detached Conditions in Metastatic Murine Mammary Cancer Cells

Regions of hypoxia are common in solid tumors and drive changes in gene expression that increase risk of cancer metastasis. Tumor cells must respond to the stress of hypoxia by activating genes to modify cell metabolism and antioxidant response to improve survival. The goal of the current study was...

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Bibliographic Details
Main Authors: Violet A. Kiesel, Madeline P. Sheeley, Emily M. Hicks, Chaylen Andolino, Shawn S. Donkin, Michael K. Wendt, Stephen D. Hursting, Dorothy Teegarden
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
breast cancer
metastasis
hypoxia
integrated stress response (ISR)
cell stress
ATF4 activating transcription factor 4
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.767479/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.767479/full

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