LINflow: a computational pipeline that combines an alignment-free with an alignment-based method to accelerate generation of similarity matrices for prokaryotic genomes

Background Computing genomic similarity between strains is a prerequisite for genome-based prokaryotic classification and identification. Genomic similarity was first computed as Average Nucleotide Identity (ANI) values based on the alignment of genomic fragments. Since this is computationally expen...

Full description

Bibliographic Details
Main Authors: Long Tian, Reza Mazloom, Lenwood S. Heath, Boris A. Vinatzer
Format: Article
Language:English
Published: PeerJ Inc. 2021-03-01
Series:PeerJ
Subjects:
Online Access:https://peerj.com/articles/10906.pdf