Efficacy of PARP Inhibitors in the Treatment of Ovarian Cancer: A Literature-Based Review

Efficacy of PARP Inhibitors in the Treatment of Ovarian Cancer: A Literature-Based Review

Poly (ADP-ribose) polymerase (PARP) inhibitors are a unique class of therapeutic agents that focus on tumors with deficiencies in the homologous recombination DNA repair mechanism. Genomic instability outlines high-grade serous ovarian cancer, with 50% of all tumors displaying defects in the importa...

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Bibliographic Details
Main Authors: Vikas Goswami, Venkata Pradeep Babu Koyyala, Sumit Goyal, Manish Sharma, Varun Goel, Nilesh Dhamne, Udip Maheshwari, Atul Sharma
Format: Article
Language:English
Published: Thieme Medical Publishers, Inc. 2019-01-01
Series:Asian Journal of Oncology
Subjects:
brca
parp inhibitors
resistance mechanism
companion diagnostic
homologous recombination
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1700619

Internet

http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1700619

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