Histidine Residues Are Responsible for Bidirectional Effects of Zinc on Acid-Sensing Ion Channel 1a/3 Heteromeric Channels

Histidine Residues Are Responsible for Bidirectional Effects of Zinc on Acid-Sensing Ion Channel 1a/3 Heteromeric Channels

Acid-sensing ion channel (ASIC) subunits 1a and 3 are highly expressed in central and peripheral sensory neurons, respectively. Endogenous biomolecule zinc plays a critical role in physiological and pathophysiological conditions. Here, we found that currents recorded from heterologously expressed AS...

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Bibliographic Details
Main Authors: Qian Jiang, Andrew M. Peterson, Yuyang Chu, Xiaolan Yao, Xiang-ming Zha, Xiang-Ping Chu
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Biomolecules
Subjects:
acid-sensing ion channels
ASIC1a
ASIC3
zinc
mutation
histidine
Online Access:https://www.mdpi.com/2218-273X/10/9/1264

Internet

https://www.mdpi.com/2218-273X/10/9/1264

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